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. 2014 Feb 17;124(3):1199–1213. doi: 10.1172/JCI70647

Figure 4. Antinociceptive responses to ANG2002 in acute pain models.

Figure 4

(A) Hot-plate test performed on CD-1 mice after administration of ANG2002 (10 and 20 mg/kg i.v.), NT (8 mg/kg i.v.), or buprenorphine (Bupe; 1 mg/kg s.c.). (B) Analgesic effects of ANG2002 and morphine sulfate (MS; 5 mg/kg i.p.), assessed by mouse radiant heat tail-flick assay. MPE was calculated at the time of peak antinociceptive response. *P < 0.05, **P < 0.01, ***P < 0.001 versus saline control, 1-way ANOVA followed by Dunnett multiple comparison test.