Figure 11. 4-PBA treatment increases muscle grip strength of plectin-deficient mice.

(A) Forelimb grip strength or (B) total grip strength (forelimbs and hind limbs) of wild-type and MCK-Cre/cKO mice was assessed before, after 10 days, and after 20 days of i.p. 4-PBA treatment using a grip strength meter. Mean ± SEM (wild-type, n = 7; MCK-Cre/cKO, n = 5). (C) Muscle grip strength was evaluated by measuring the hang time on an inverted wire mesh grid. Mean ± SEM (wild-type, n = 6; MCK-Cre/cKO, n = 5). *P < 0.05, **P < 0.01, paired Student’s t test.