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. 2014 Feb 3;124(3):1144–1157. doi: 10.1172/JCI71919

Figure 2. Spontaneous collapse of desmin IF networks upon plectin deficiency.

Figure 2

(A) Desmin-specific immunostaining of Plec+/+ and Plec–/– myotubes (differentiated for 10 days). Plec–/– myotubes with partially collapsed networks and massive desmin aggregates are shown in top and middle images, respectively. Scale bars: 10 μm. (B) Statistical analysis of desmin aggregate formation in Plec+/+ and Plec–/– myotubes differentiated for 5 (Plec+/+, n = 436 myotubes; Plec–/–, n = 383 myotubes), 10 (Plec+/+, n = 363 myotubes; Plec–/–, n = 356 myotubes), or 15 (Plec+/+, n = 420 myotubes; Plec–/–, n = 278 myotubes) days. Mean ± SEM, 4 experiments. (C) Statistical evaluation of desmin aggregate formation in primary myotubes differentiated for 10 days (Plec+/+, n = 87 myotubes; Plec–/–, n = 164 myotubes). Mean ± SEM, 3 experiments.

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