Figure 6. Accumulation of chaperones in desmin-positive protein aggregates in Plec–/– muscle fibers.
Immunolocalization of HSPs on teased EDL fibers from 3-month-old wild-type and MCK-Cre/cKO mice. Note colocalization of all 4 chaperones tested with desmin-positive IF aggregates in plectin-deficient fibers. Scale bars: 20 μm.