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. 2014 Feb 3;124(3):1144–1157. doi: 10.1172/JCI71919

Figure 8. 4-PBA treatment of differentiated Plec–/– myotubes stabilizes desmin and α-actinin dynamics.

Figure 8

(A) FRAP analyses of desmin-GFP in Plec+/+ and Plec–/– myotubes differentiated for 10 days with and without 1 mM 4-PBA. Mean ± SEM, 2 experiments (untreated: Plec+/+, n = 54 analyzed ROIs; Plec–/–, n = 55 analyzed ROIs; 4-PBA–treated: Plec+/+, n = 29 analyzed ROIs; Plec–/–, n = 31 analyzed ROIs). (B) FRAP analysis of α-actinin–GFP under conditions similar to those in A. Mean ± SEM, 2 experiments (untreated: Plec+/+, n = 38 analyzed ROIs; Plec–/–, n = 45 analyzed ROIs; 4-PBA–treated: Plec+/+, n = 21 analyzed ROIs; Plec–/–, n = 30 analyzed ROIs).

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