Table.

Sequence variants at the parkin and PINK1 loci in 87 MSA cases

Nucleotide Change	Amino Acid Change	Location	Mutation Type	Alleles in Cases	Alleles in Controls†	p value
parkin
c.258C>T	p.Arg42Cys	exon 2	missense	1 / 175	0 / 552	0.242
c.272+25C	-	intron 2	intronic	34 / 142	115 / 437	0.747
c.514-20T	-	intron 3	intronic	13 / 163	44 / 508	0.873
c.601G>A	p.Ser167Asn	exon 4	missense	2 / 174	9 / 543	1
c.835G>A	p.Arg234Gln	exon 6	missense	1 / 175	0 / 552	0.242
c.1239G>C	p.Val380Leu	exon 10	missense	33 / 143	99 / 453	0.823
c.1281G>A	p.Asp394Asn	exon 11	missense	12 / 162	14 / 538	0.016
c.1444C>T	p.Pro437Leu	exon 12	missense	1 / 175	0 /552	0.242
PINK1
c.283C>T	p.Leu63Leu	exon 1	silent	36 / 130	88 / 464	0.101
c.438A>T	p.Gln115Leu	exon 1	missense	12 / 154	32 / 520	0.467
c.482-7A	-	intron 1	intronic	21 / 147	69 / 483	1
c.661C>A	p.Gly189Gly	exon 2	silent	1 / 167	0 / 552	0.233
c. 1054-5G	-	intron 4	intronic	20 / 156	67 / 485	0.894
c.1105C>T	p.Arg337Arg	exon 5	silent	1 / 175	0 / 552	0.242
c.1112G>A	p.Ala340Thr	exon 5	missense	9 / 167	18 / 534	0.257
c.1189C>T	p.Ser365Ser	exon 5	silent	1 / 175	0 / 552	0.242
c.1656A>C	p.Asn521Thr	exon 8	missense	53 / 121	152 / 400	0.499

^†mutational screening results of normal controls have been published elsewhere (see Brooks et al., 2009).