Table I.
Impact of Buzzy® on routine haematology tests.
| Tests | Units | Desirable bias (%) | CVa | Buzzy® | Gold standard | Mean % difference | P-value |
|---|---|---|---|---|---|---|---|
| RBC** | (1012/L) | 1.7 | 1.5 | 4.90±0.55 | 4.80±0.55 | 2.0 | 0.0006 |
| Hb** | (g/L) | 1.8 | 1.0 | 141.4±13.2 | 137.9±12.7 | 2.5 | 0.0002 |
| Hct** | (%) | 1.7 | 1.5 | 41.5±4.0 | 40.6±4.0 | 2.2 | 0.0005 |
| MCV* | (fL) | 1.2 | 1.0 | 84.6 (81.9–88.1) | 84.4 (81.8–88.3) | 0.2 | 0.6245 |
| RDW** | (%) | 1.7 | 2.0 | 12.7±0.6 | 12.7±0.5 | 0.0 | 0.3343 |
| WBC** | (109/L) | 5.6 | 3.0 | 7.10±1.89 | 7.35±1.94 | −3.5 | 0.0099 |
| NEU** | (106/L) | 9.1 | 8.0 | 4.15±1.49 | 4.27±1.57 | −2.9 | 0.0256 |
| LYMP** | (106/L) | 7.4 | 8.0 | 2.32±0.80 | 2.41±0.80 | −3.9 | 0.0425 |
| MONO** | (106/L) | 13.2 | 9.8 | 0.28±0.05 | 0.29±0.08 | −3.6 | 0.4431 |
| EOS** | (106/L) | 19.8 | 15.5 | 0.16±0.07 | 0.16±0.08 | 0.0 | 0.6165 |
| BASO** | (106/L) | 15.4 | 9.7 | 0.041±0.02 | 0.046±0.02 | −12.2 | 0.0894 |
| PLT** | (109/L) | 5.9 | 4.0 | 272±66 | 274±66 | −0.7 | 0.3705 |
| MPV** | (fL) | 2.3 | 1.2 | 9.09±0.71 | 9.12±0.81 | −s0.3 | 0.7116 |
Non-normal distribution; the values are presented as median (interquartile range); P-value represents the significance by Wilcoxon ranked-pairs test.
Normal distribution; the values are presented as mean ± standard deviation; P-value represents the significance by paired Student’s t-test. The P-values in bold are statistically significant (P <0.001) and bold mean % differences represent clinically significant variations, when compared with desirable bias24.
RBC: red blood cell count; Hct: haematocrit; Hb: haemoglobin concentration, MCV: mean corpuscular volume; RDW: red blood cell distribution width; WBC: white blood cell count; NEU: neutrophil count; LYMP: lymphocyte count; MONO: monocyte count; EOS: eosinophil count; BASO: basophil count; PLT: platelet count; MPV: mean platelet volume.