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. 2014 Feb 25;5:21. doi: 10.3389/fpsyt.2014.00021

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Copyright © 2014 Rahm, Liberg, Kristoffersen-Wiberg, Aspelin and Msghina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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fMRI results. (A,B) Brain activation during affective counting Stroop (aStroop) and cognitive counting Stroop (cStroop), before (controls) and after intake of escitalopram (cluster forming threshold Z ≥ 2.3, corrected p = 0.05, MNI z = 29). In both Stroop conditions, there are significant activations in anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex, key nodes in the neural cognitive control networks. (C) A region of interest analysis of the ACC, where aStroop activates more than cStroop before compared to after drug intake. For display purposes the cluster shown in the image has an uncorrected threshold of 0.005, but the peak voxel (x, y, z: 6, 44, 12) survived a corrected threshold of p = 0.05 (at the voxel level, using Gaussian random field theory).