TABLE 4.

Higher Number of Invasive Procedures Was Associated With Lower FA at Age 7 Years

	Fractional Anisotropy
Predictors	Pain Model, n = 50			Surgery Model, n = 50			Steroid Model, n = 50
	Effect Size	CI	P	Effect Size	CI	P	Effect Size	CI	P
Number of invasive procedures	−0.02	−0.04 to −0.005	.01	−0.02	−0.04 to −0.006	.007	−0.02	−0.04 to -0.006	.01
GA	−0.001	−0.004 to 0.003	.71	−0.001	−0.004 to 0.003	.73	−0.001	−0.005 to 0.004	.76
Small for GA	−0.003	−0.02 to 0.01	.68	−0.003	−0.02 to 0.01	.67	−0.005	−0.02 to 0.01	.52
Illness severity	<0.001	−0.0004 to 0.001	.57	<0.001	−0.0004 to 0.001	.65	<0.001	−0.001 to 0.001	.84
Mechanical ventilation	−0.003	−0.02 to 0.01	.70	−0.002	−0.02 to 0.01	.78	<0.001	−0.01 to 0.02	1.00
Postnatal infection	0.009	−0.004 to 0.02	.16	0.008	−0.005 to 0.02	.21	0.008	−0.006 to 0.02	.26
Gender	−0.002	−0.01 to 0.007	.71	−0.002	−0.01 to 0.008	.72	−0.004	−0.01 to 0.007	.49
Age at scan	−0.19	−0.47 to 0.08	.17	−0.20	−0.48 to 0.09	.17	−0.18	−0.46 to 0.10	.21
Brain injury	−0.009	−0.02 to 0.002	.10	−0.009	−0.02 to 0.002	.10	−0.007	−0.02 to 0.003	.16
Surgery	—	—	—	0.002	−0.02 to 0.02	.84	—	—	—
Morphine exposure	0.008	−0.007 to 0.02	.28	0.008	−0.009 to 0.03	.37	0.003	−0.02 to 0.02	.77
Fentanyl exposure	—	—	—	<−0.001	−0.0001 to 0.00002	.24	—	—	—
Corticosteroids	—	—	—	—	—	—	−0.007	−0.02 to 0.01	.43
Midazolam	—	—	—	—	—	—	0.001	−0.0003 to 0.001	.22