TABLE 3.
Characteristics of Studies That Assessed Obesity in Pediatric ALL Survivors Off Treatment ≥10 Years
| Author, Year (Location) | Study Design | Type of Controla | Survivors, n /(Control) | Years at Dx | Age at Studyb | Years Since Dxb | % CRT | Major Findingsc | By Genderd | By CRTd |
|---|---|---|---|---|---|---|---|---|---|---|
| BMI z score | ||||||||||
| Birkebaek et al 1998 (Denmark) | L | Normative (French) | 33 | 1973–1984 | 20.5 | 16.2 | 66.7 | 1.3 | N/A | CRT+: 1.4, CRT –: 1.0 |
| Veringa et al 2012 (Netherlands) | CS | Normative (Dutch) | 68 | 1973–2000 | 25.0 | 18.2 | 45.6 | 0.5 | M: –0.1, F: 1.4 | CRT+: 1.0, CRT–: 0.02 |
| BMI | ||||||||||
| Brennan et al 1999 (UK) | CS | External | 32/35 | MRC UKALL I-X | 23.0 | 17.8 | 100 | 24.3/23.7 | M: 24.0, F: 24.7 | N/A |
| Oeffinger et al 2003 (US) | CS | External (sibling) | 1765/2565 | 1970–1986 | 24.1 | 17.1 | 76.1 | 25.2/25.1 | M: 25.5, F: 24.9 | CRT+: 25.5, CRT–: 24.4 |
| Ness et al 2007 (US) | CS | Normative | 75 | 1970–1986 | 30.2 | 24.6 | 66.7 | 27.4/27.1 | M: 26.8, F: 27.9 | N/A |
| Garmey et al 2008 (US) | CS | External (sibling) | 1451/2167 | 1970–1986 | 32.3 | 25.1 | 76.7 | 27.9/26.8 | M: 27.9, F: 27.9 | CRT+: 28.4, CRT–: 26.4 |
| Geenen et al 2010 (Netherlands) | CS | External (sibling) | 79/69 | 1966–1991 | 24.5 | 20.8 | 60.8 | 24.0/23.9 | N/A | CRT+: 24.7, CRT–: 22.9* |
| % fat | ||||||||||
| Brennan et al 1999 (UK) | CS | External | 32/35 | MRC UKALL I-X | 23.0 | 17.8 | 100 | 32.3/26.2* | M: 25.8, F: 39.7 | N/A |
| Ness et al 2007 (US) | CS | Normative | 75 | 1970–1986 | 30.2 | 24.6 | 66.7 | 33.0/30.0* | M: 26.0, F: 38.0 | N/A |
| % OW/OB | ||||||||||
| Birkebaek et al 1998 (Denmark) | L | Normative (French) | 33 | 1973–1984 | 20.5 | 18.7 | 66.7 | OB: 36% | N/A | None |
| Shaw et al 2000 (UK) | CS | Normative (British) | 33 | 1971–1989 | 23.2 | 17.1 | 100 | OW/OB: 45% | M: 13%, F: 56% | N/A |
| Oeffinger et al 2003 (US) | CS | External (sibling) | 1765/2565 | 1970–1986 | 24.1 | 17.1 | 76.1 | OW: 29%, OB: 17% | M: 51%, F: 49% | CRT+: 47%, CRT–: 37% |
| van Beek et al 2006 (Netherlands) | CS | Normative (Dutch) | 90 | N/A | 21.2 | 12.7 | 21.1 | OW: 26%, OB: 8%, OW/OB: 38% | N/A | N/A |
| Veringa et al 2012 (Netherlands) | CS | Normative (Dutch) | 68 | 1973–2000 | 24.0 | 18.2 | 46.0 | M: 21%, F: 65% | CRT+: 90%, CRT–: 30%* | |
CRT+, survivors treated with CRT; CRT–, survivors treated with no CRT; CS, cross-sectional; Dx, diagnosis; F, female survivors; L, longitudinal; M, male survivors; MRC, Medical Research Council; N/A, values were not presented for subgroups; OB, obesity; OW, overweight.
Normative controls are reference populations used to calculate BMI z score or percentile. External controls are usually age- and/or gender-matched healthy unrelated individuals unless sibling controls are indicated.
Age at study and year since Dx are the mean or median as reported or estimated on the basis of the reported age at diagnosis and duration of follow-up (the mean duration of treatment was estimated to be 2.5 y if not indicated by the study).
Weighted average was calculated if values were provided separately for subgroups (eg, M and F, survivors treated with CRT and without CRT).
None: the study indicated no difference by subgroups, but the actual values were not reported for subgroups. Yes: the study indicated a difference by subgroups but the actual values were not reported for subgroups.
The study reported the subgroup difference was statistically different (P < .05).