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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Osteoarthritis Cartilage. 2013 Nov 2;22(1):51–62. doi: 10.1016/j.joca.2013.10.014

Table II.

MF mean values (95% CI, estimated differences) of each variable cross-sectionally (linear regression models adjusting for age, gender, BMI)

T1ρ Global (ms) Estimated difference 95% CI P-value T1ρ Articular layer (ms) Estimated difference 95% CI P-value T1ρ Bone layer (ms) Estimated difference 95% CI P-value
Baseline Control 41.93 0.811 –1.926, 3.5 0.56 47.16 1.082 –1.94, 4.1 0.48 36.43 0.387 –2.7, 3.4 0.8
Lesion 45.55 51.62 39.31
1 Year Control 41.48 3 0.553, 5.5 0.017 47.37 3.4 0.69, 6.2 0.015 35.26 2.5 –0.61, 5.5 0.11
Lesion 45.88 52.55 38.99
2 Year Control 41.48 3.9 0.664, 7.2 0.02 47.40 3.4 –0.25, 7.0 0.067 35.28 3.8 –0.59, 8.2 0.088
Lesion 47.77 54.20 41.01
3 Year Control 40.28 2.3 –0.274, 4.9 0.077 47.37 1.321 –2.69, 5.3 0.5 32.82 4.60 2.1, 7.2 0.001
Lesion 43.60 50.04 37.24
T1ρ Contrast-horizontal Estimated difference 95% CI P-value T1ρ Contrast-vertical Estimated difference 95% CI P-value
Baseline Control 10.62 23 8.6, 37 0.002 81.84 41 8.4, 73 0.014
Lesion 35.32 148.90
1 Year Control 9.43 16 –3.76, 36 0.11 81.23 36 4, 69 0.028
Lesion 30.09 137.36
2 Year Control 6.22 22 4.8, 40 0.015 85.65 81 29, 134 0.0034
Lesion 33.88 202.60
3 Year Control 9.51 10.2 –7.38, 28 0.24 95.41 –5.678 –37.66, 26 0.72
Lesion 22.37 100.51
T1ρ Entropy-horizontal Estimated difference 95% CI P-value T1ρ Entropy-vertical Estimated difference 95% CI P-value
Baseline Control 5.26 0.211 0.039, 0.382 0.017 5.55 0.225 0.07, 0.34 0.004
Lesion 5.56 5.84
1 Year Control 5.21 0.258 0.102, 0.414 0.0016 5.61 0.251 0.11, 0.40 0.001
Lesion 5.54 5.89
2 Year Control 5.13 0.271 0.057, 0.484 0.015 5.64 0.13 –0.10, 0.36 0.25
Lesion 5.52 5.83
3 Year Control 5.28 0.047 –0.183, 0.277 0.68 5.74 0.031 –0.22, 0.28 0.8
Lesion 5.41 5.84
T1ρ Variance-horizontal Estimated difference 95% CI P-value T1ρ Variance-vertical Estimated difference 95% CI P-value
Baseline Control 72.35 85 55, 116 <0.0001 66.05 77 48, 106 <0.0001
Lesion 185.54 167.22
1 Year Control 75.92 73 43, 103 <0.0001 68.04 57 32, 82 <0.0001
Lesion 167.96 141.72
2 Year Control 80.14 127 67, 187 0.0001 71.43 85 39, 130 0.0006
Lesion 232.83 183.11
3 Year Control 97.18 32 –43.08, 107 0.39 85.56 24 –31.89, 80 0.38
Lesion 148.24 125.27
T2 Global mean (ms) Estimated difference 95% CI P-value T2 Articular layer (ms) Estimated difference 95% CI P-value T2 Bone layer (ms) Estimated difference 95% CI P-value
Baseline Control 31.82 1.349 –0.929, 3.6 0.24 33.60 1.753 –0.699, 4.2 0.16 29.93 1.003 –0.97, 3.2 0.42
Lesion 34.88 37.38 32.33
1 Year Control 30.58 3.8 1.781, 1.551 0.0004 32.37 3.7 1.551, 5.8 0.001 28.67 4 1.52, 6.4 0.002
Lesion 35.39 37.37 33.32
2 Year Control 31.18 2.6 0.162, 5.1 0.038 32.68 2.4 –0.048, 4.9 0.054 29.60 2.9 –0.30, 6.1 0.074
Lesion 35.30 37.39 33.16
3 Year Control 29.64 4.1 1.74, 6.5 0.0016 32.07 3.7 0.985, 6.4 0.0098 27.05 2.3, 6.8 0.0004
Lesion 34.41 36.89 31.80 4.60
T2 Contrast-horizontal Estimated difference 95% CI P-value T2 Contrast-vertical Estimated difference 95% CI P-value
Baseline Control 10.66 11.9 –2.284, 26 0.099 59.12 63 28, 99 0.0007
Lesion 25.26 139.79
1 Year Control 4.08 8.4 3.5, 13.3 0.0012 53.76 42 19.1, 65 0.0006
Lesion 13.60 100.70
2 Year Control 3.35 9.9 3.5, 16.3 0.0035 48.85 47 8.4, 86 0.019
Lesion 13.92 113.73
3 Year Control 3.16 2.2 0.299, 4 0.025 45.14 16.2 1.878, 31 0.028
Lesion 5.70 66.65
T2 Entropy-horiizontal Estimated difference 95% CI P-value T2 Entropy-vertical Estimated difference 95% CI P-value
Baseline Control 5.09 0.094 –0.05, 0.24 0.19 5.48 0.056 –0.11, 0.22 0.49
Lesion 5.32 5.61
1 Year Control 4.90 0.25 0.09, 0.41 0.003 5.45 0.134 –0.01, 0.28 0.064
Lesion 5.27 5.66
2 Year Control 4.84 0.166 –0.05, 0.38 0.13 5.48 –0.087 –0.26, 0.09 0.31
Lesion 5.13 5.48
3 Year Control 4.86 0.107 –0.07, 0.29 0.23 5.47 0.083 –0.10, 0.28 0.36
Lesion 5.07 5.66
T2 Variance-horizontal Estimated difference 95% CI P-value T2 Variance-vertical Estimated difference 95% CI P-value
Baseline Control 73.12 78 39, 117 0.0001 67.09 50 22, 78 0.0006
Lesion 186.63 146.76
1 Year Control 68.57 61 30, 92 0.0002 61.54 47 22, 73 0.0005
Lesion 139.81 116.40
2 Year Control 63.52 101 32, 169 0.0056 57.00 59 11.9, 107 0.016
Lesion 180.03 136.00
3 Year Control 64.19 18.1 –6.19, 42 0.14 56.86 12.3 –5.936, 31 0.18
Lesion 92.75 78.23

The bold indicates significance at P < 0.05.