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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Genet. 2013 Dec 15;46(2):152–160. doi: 10.1038/ng.2853

Figure 5. PABPC1 is mislocalized in motor neurons from ALS patient tissue.

Figure 5

a–d, Immunostaining for PABPC1 in the cervical spinal cord of control and ALS patients.

a) PABPC1 is expressed in spinal cord motor neurons, and is localized throughout the cytoplasm in a diffuse pattern.

b) Occasionally PABPC1 cytoplasmic accumulations were observed in normal motorneurons (arrow).

c) In ALS patient motor neurons, PABPC1 is present in distinct cytoplasmic and dense accumulations (arrow).

d) PABPC1 cytoplasmic accumulations were also observed in the ALS motorneurons where there was a clearing in the middle. Scale bars, 30 μm.

e) The number of motor neurons containing cytoplasmic accumulation of PABPC1 in ALS patients was significantly greater (p=0.01, one-tailed Mann-Whitney test) than in motor neurons from controls. For quantification of accumulations of PABPC1 in individual normal versus ALS cases, see Supplementary Table 1. n=5 controls, 4 ALS patients, mean ± s.e.m.