Table 1.
Genes that suppress or enhance TDP-43 toxicity in yeast when overexpressed
| Effect | Gene | Human Homolog | Description |
|---|---|---|---|
| Suppressor | ADY3 | CENPE | Protein wall formation |
| Suppressor | BFR1 | Component of mRNP complexes associated with polyribosomes | |
| Suppressor | CYC8 | Transcription co-repressor; part of complex that recruits SWI/SNF and SAGA complexes to promoters | |
| Suppressor | FMP48 | STK36 | Protein of unknown function |
| Suppressor | HSP104 | Heat shock protein chaperon | |
| Suppressor | ICS2 | Protein of unknown function | |
| Suppressor | NNK1 | DCLK1 | Protein kinase; interacts with TORC1, Ure2p and Gdh2p |
| Suppressor | PGM1 | PGM1 | Phosphoglucomutase |
| Suppressor | RDR1 | Transcriptional repressor | |
| Suppressor | RIM15 | STK38 | Glucose-repressible protein kinase |
| Suppressor | TIS1 | ZNF36/TTP | mRNA-binding protein; component of stress granules |
| Suppressor | VTS1 | SAM4B/Smaug | RNA-binding protein containing a SAM domain; component of P granules |
| Suppressor | XRS2 | Protein required for DNA repair | |
| Enhancer | CDC6 | CDC6 | Essential ATP-binding protein required for DNA replication |
| Enhancer | DIP5 | SLC7A7 | Dicarboxylic amino acid permease |
| Enhancer | HRP1 | Musashi 1 & 2 | RNA binding protein; component of stress granules |
| Enhancer | KEL1 | RAB9 | Protein required for proper cell fusion and cell morphology |
| Enhancer | KEM1 | XRN1 | 5′-3′ exonuclease component of P bodies |
| Enhancer | KIN3 | NEK2 | Serine/threonine protein kinase |
| Enhancer | MEC1 | ATR | Genome integrity checkpoint protein |
| Enhancer | MSA1 | Mucin 17 | Involved in regulation of timing of G1-specific gene transcription and cell cycle initiation |
| Enhancer | MSN5 | XPO5 | Karyopherin involved in nuclear import and export |
| Enhancer | MTH1 | Negative regulator of the glucose-sensing signal transduction pathway | |
| Enhancer | PBP1 | Ataxin 2 | Interacts with Pab1p; component of stress granules |
| Enhancer | PBP2 | PCBP1, 2, 3, & 4 | RNA binding protein |
| Enhancer | PCL6 | Pho85p cyclin of the Pho80p subfamily | |
| Enhancer | PIB2 | WDFY3 | Protein binding phosphatidylinositol 3-phosphate |
| Enhancer | RGA2 | ARHGAP15 | GTPase-activating protein for Cdc42p |
| Enhancer | ROM2 | NET1 | GDP/GTP exchange protein (GEP) for Rho1p and Rho2p |
| Enhancer | SAK1 | CAMKK1 | Upstream kinase for the SNF1 complex |
| Enhancer | SFG1 | Putative transcription factor | |
| Enhancer | SLF1 | LARP1 | RNA binding protein that associates with polysome |
| Enhancer | SLG1 | Sensor-transducer of the stress-activated PKC-MPK1 kinase pathway | |
| Enhancer | SOL1 | PGLS | Protein with possible role in tRNA transport |
| Enhancer | SRO9 | LARP2 | RNA-binding protein that associates with translating ribosomes |
| Enhancer | TSC11 | RICTOR | Subunit of TORC2 |
| Enhancer | UBP7 | USP21 | Ubiquitin-specific protease |
| Enhancer | VHS1 | MARK2 | Cytoplasmic serine/threonine kinase |
| Enhancer | YCK2 | CSNK1G2 | Casein kinase 1 isoform |
| Enhancer | YHR131C | Putative protein of unknown function |
Descriptive information from the Saccharomyces Gene Database, www.yeastgenome.org