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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Am J Hematol. 2012 Mar 3;87(0 1):S4–11. doi: 10.1002/ajh.23142

Figure 5.

Figure 5

The life-cycle of von Willebrand factor from gene expression to receptor-mediated clearance. Pathogenic mechanisms localized to any of these processes can result in a reduction in plasma VWF levels.