Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Primary structure of the von WiIlebrand factor (VWF) pre-pro-polypeptide and its ligands. There is a typical 22 amino acid (AA) hydrophobic signal peptide, a large 741 AA propeptide responsible for facilitating N-terminally aligned multimer formation, and a 2050 AA secreted mature VWF subunit containing the binding sites for FVIII, platelets and the subendothelium. CK=cysteine knot domain.
