Table II.

Novel genetic associations with plasma von Willebrand factor levels as determined by the CHARGE genome-wide association meta-analysis (Smith et al, 2010). Of the five genes identified by this strategy in the initial discovery populations and in an independent replication cohort, two encode proteins involved in vesicular trafficking, storage and secretion, and three encode receptor proteins that might contribute to VWF clearance.

CHARGE GWAS-identified Novel Genetic Loci associated with plasma VWF levels
Vesicular trafficking and exocytosis proteins
a) STXBP5	Syntaxin binding protein 5
b) STX2	Syntaxin 2
Receptor proteins
a) SCARA5	Scavenger receptor class A member 5
b) STAB2	Stabilin 2
c) CLEC4M	C-type Lectin Type 4 Member M