Table III.
Summary of the prevalence, mutation detection success rates and potential clinical utility of molecular genetic testing for the various subtypes of von Willebrand disease (VWD). Note that the prevalence figures for the various type 2 forms of VWD vary significantly between different geographical locations.
| Type of VWD |
Prevalence (%) |
Molecular Test Success (%) |
Utility of Diagnostic Molecular Analysis |
|---|---|---|---|
| 1 | 75% | ~65% | Currently not beneficial |
| 2A | ~8% | ~85% | Confirmatory of phenotypic analysis |
| 2B | ~8% | ~85% | Confirmatory of phenotypic analysis |
| 2M | ~2% | ~85% | Confirmatory of phenotypic analysis |
| 2N | ~8% | ~85% | Confirmatory of phenotypic analysis |
| 3 | <1% | ~85% | Prenatal testing |