Figure 3.

(A) Results from screening a library of compounds, aimed at inhibiting dual specificity and tyrosine phosphatases, for their effect on intracellular growth of S. typhimurium. The effect of small molecules on intracellular S. typhimurium growth is quantified by flow cytometry, and the results are expressed as a Z-score. The gray lines depict the variation in the triplicate data points. (B) Effects and structures of the most potent inhibitors of bacterial infection are depicted. Shown is Z-score and standard deviation of triplicate measurements.