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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Nat Neurosci. 2013 Nov 24;17(1):121–130. doi: 10.1038/nn.3588

Figure 6.

Figure 6

Validation of methylation and gene expression changes in an independent cohort. (a) Summary of Sequenom assays for DNA methylation differences tested in an independent cohort (control n = 20 DNA samples, multiple sclerosis n = 10 DNA samples). Listed are CpGs that overlap probes tested by the Illumina array. (b) Quantitative PCR of CTSZ (P = 0.021) and HAGHL (P = 0.048) in a second cohort of NAWM samples. Bar graphs (mean ± s.e.m.) show relative transcript abundance as compared to control after normalization (*P < 0.05). (c) Gene expression of NDRG1 (P = 0.0309) and LGMN (P = 0.0209) from an unpublished microarray study, showing relative transcript levels (mean ± s.e.m.) as compared to control after normalization (*P < 0.05). MS, multiple sclerosis.