FIG. 5.

Astro- and microglial activation in insula and amygdala at 6 months postinjury. LFPI+vehicle rats had increased reactive gliosis postinjury, as evidenced by increased glial activation, compared to controls, and treatment with MN166 reduced gliosis levels in LFPI rats to those of sham-operated controls. (A and B) LFPI+vehicle rats had significantly increased in GFAP labeling in both regions, indicating higher astroglial activation, compared to sham-operated and LFPI+MN166-treated rats. (C) In the CE, microglial activation was greater in LFPI+vehicle-injected rats, compared to both sham-operated groups and LFPI+MN166-treated rats, and was approaching significance in BLA. Data represent mean±standard error of the mean. LFPI, lateral fluid percussion injury; GFAP, glial fibrillary acidic protein; CE, central amagdala; BLA, basolateral amygdala.