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Comparison of key chemical and structural properties of tivozanib and sorafenib.27, 48 Sorafenib served as a comparator to tivozanib in the phase III TIVO-1 study in mRCC.
| Characteristic | Tivozanib | Sorafenib |
|---|---|---|
| MW | 454.863 | 464.824 |
| VEFR1 IC50 | 0.21 nmol/L | 26 nmol/L |
| VEFR2 IC50 | 0.16 nmol/L | 90 nmol/L |
| VEFR3 IC50 | 0.24 nmol/L | 100 nmol/L |
| 2-D Structure |
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| 3-D Structure |
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