Tabe 4.

IMDC risk group criteria for OS in nccRCC

	Univariate analysis		Multivariable model*
Parameter	HR (95% CI)	p-value	HR (95% CI)	p-value
Hb low (<LLN)	1.72(1.23,2.40)	0.002	1.48(1.03,2.14)	0.034
Neutrophilia (>ULN)	3.23(2.24,4.65)	<.0001	2.43(1.58,3.74)	<.0001
KPS <80	3.15(2.23,4.45)	<.0001	2.02(1.35,3.02)	0.0006
Thrombophilia (>ULN)	2.56(1.80,3.63)	<.0001	1.13(0.72,1.79)	0.592
Hypercalcaemia (>ULN)	2.13(1.24,3.65)	0.006	1.42(0.78,2.60)	0.256
Dx to treatment initiation <1year	1.53(1.12,2.07)	0.007	1.22(0.87,1.71)	0.251

Abbreviations: Hb= hemoglobin, KPS= Karnofski performance status, Dx= diagnosis, ULN= upper limit of normal, LLN= lower limit of normal

^*c-index of 0.70 (95% CI: 0.66-0.74),