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Model for HSF1 and autophagy in cellular response to Hsp90 inhibitors. HSF1 is activated by Hsp90 inhibitors and enhances the activity of the transcription factor HSF1, which by promoting the expression of p62/SQSTM1 maintains autophagic and mitigates cell death. Inhibiting HSF1 or autophagy increases cellular sensitivity to cell death following treatment with Hsp90 inhibitors.
