Table 3.
DSC parameters of the lipid blends with different liquid lipid contents
| PLL (%) |
TE | OT (°C) |
MP (°C) |
Enthalpy (J/g) |
WME (°C) |
|---|---|---|---|---|---|
| 0 | Endothermic | 68.11 | 73.51 | 127.13 | 6.44 |
| 10 | Endothermic | 57.14 | 67.68 | 117.08 | 13.95 |
| 20 | Endothermic | 51.16 | 61.95 | 84.88 | 16.21 |
| 30 | Endothermic | 52.00 | 62.79 | 104.55 | 16.23 |
| 40 | Endothermic | 53.45 | 63.47 | 114.99 | 15.98 |
| 50 | Endothermic | 63.34 | 69.86 | 118.64 | 8.57 |
Notes: The selected solid lipid (Compritol 888 ATO) and liquid lipid (Capryol 90) were mixed in different ratios. Lipid blends were agitated at 200 rpm at 85°C for 1-hour and subsequently cooled with cold water (2°C–4°C), which aimed to mimic the production process of lipid nanoparticles by microemulsion technique.
Abbreviations: DSC, differential scanning calorimetry; MP, melting point; OT, onset temperature; PLL, percentage of liquid lipid; TE, thermal event; WME, width of the melting event.