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. 2014 Feb 20;8:263–277. doi: 10.2147/DDDT.S55045

Figure 8.

Figure 8

Antinociception: effects of 4d and 4e on the hot plate test. Bars show percent MPE (mean ± SEM, n≤10) induced by morphine 10 mg/kg, 4d 10 mg/kg, 4e 10 mg/kg, naloxone 1 mg/kg, and rimonabant 1 mg/kg administered 20 minutes after treatment with 4d 10 mg/kg, 4e 10 mg/kg, naloxone 1 mg/kg, or rimonabant 1 mg/kg. Statistically significant versus control value; ###P<0.001. Significant difference versus morphine; **P<0.01 (one-way analysis of variance, Newman–Keuls post hoc test).

Notes: Morphine (Sigma-Aldrich, Madrid, Spain); naloxone (Tocris/Biogen Científica SL, Madrid, Spain); rimonabant (Sanofi, Paris, France).

Abbreviations: MF, morphine; Nx, naloxone; SEM, standard error of the mean; SR, rimonabant; MPE, maximum possible effect.