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Effects of statins on NADPH oxidase in EC. Statins suppress expression of p22phox and reduce levels of p47phox and Nox2. In addition, by lowering synthesis of GGPP, they prevent activation of Rac1 and translocation to the membrane, thus preventing activation of the Nox2 complex in the endothelium. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
