Table 4.
Brain Locations of Lower Macromolecular Proton Fraction MPF in Blast-Mild Traumatic Brain Injury Veterans with 1–5, 6–19, and 20–100 Blast Exposures, Respectively, Compared with Nonblast Veterans
| Veterans with 1–5 blast-mTBIs (n=10) compared with nonblast veterans (n=16) | |||
|---|---|---|---|
| Structurea | Tissueb | Coordinates (mm)c | Z-scored |
| R pyramis (cerebellum) | GM | (−19, −64, −27) | 4.45 |
| GM | (−17, −73, −32) | 3.99 | |
| L middle temporal gyrus | GM | (66, −37, −4) | 4.09 |
| R medial frontal gyrus | WM | (−6, 28, 34) | 4.28 |
| GM | (−3, 39, 25) | 3.97 | |
| R postcentral gyrus | WM | (−15, −35, 47) | 3.98 |
| L lingual gyrus | WM | (12, −91, −11) | 4.32 |
| R precuneus | WM | (−8, −64, 20) | 4.08 |
| R cuneus | GM | (−1, −62, 16) | 3.96 |
| Veterans with 6–19 blast-mTBIs (n=8) compared with nonblast veterans (n=16) | |||
|---|---|---|---|
| Structurea | Tissueb | Coordinates (mm)c | Z-scored |
| L Precuneus | WM | (12, −64, 34) | 3.95 |
| Veterans with 20–100 blast-mTBIs (n=9) compared with nonblast veterans (n=16) | |||
|---|---|---|---|
| Structurea | Tissueb | Coordinates (mm)c | Z-scored |
| R superior frontal gyrus | GM/WM | (−21, 57, 22) | 4.85 |
| GM/WM | (−10, 66, 0) | 4.07 | |
| GM | (−24, 59, 27) | 4.57 | |
| GM | (−15, 66, 20) | 4.56 | |
| GM | (−24, 66, 7) | 3.98 | |
| WM | (−17, 53, 7) | 4.24 | |
| WM | (−17, −10, 45) | 4.20 | |
| L superior frontal gyrus | GM/WM | (26, 50, 18) | 4.08 |
| L inferior frontal gyrus | GM/WM | (39, 5, 20) | 4.54 |
| R middle frontal gyrus | GM/WM | (−37, 48, −4) | 4.32 |
| GM/WM | (−42, 41, 14) | 4.17 | |
| GM/WM | (−44, 26, 18) | 4.04 | |
| GM | (−46, 50, −4) | 3.96 | |
| WM | (−28, 50, 20) | 4.12 | |
| WM | (−35, 3, 40) | 4.10 | |
| WM | (−39, 35, 32) | 4.10 | |
| R precentral gyrus | WM | (−21, −19, 45) | 4.26 |
| L precentral gyrus | WM | (17, −19, 40) | 4.08 |
| (15, −17, 47) | 4.06 | ||
| R postcentral gyrus | WM | (−37, 3, 45) | 4.14 |
| L postcentral gyrus | WM | (57, −13, 22) | 4.18 |
| (19, −33, 40) | 4.09 | ||
| R middle temporal gyrus | GM/WM | (−60, −31, −4) | 4.13 |
| L superior parietal lobule | WM | (19, −62, 27) | 4.54 |
| (28, −46, 38) | 4.20 | ||
| R cingulate gyrus | GM | (−3, 30, 27) | 4.19 |
| L cingulate gyrus | WM | (3, −28, 32) | 4.10 |
| R precuneus | WM | (−21, −60, 43) | 4.21 |
| GM | (−1, −64, 18) | 3.99 | |
| GM | (−3, −96, 16) | 4.19 | |
| GM | (−10, −94, 11) | 3.98 | |
| R cingulum (hippocampal part) | WM | (−17, −46, 2) | 4.06 |
| L cingulum | WM | (3, −15, 32) | 4.74 |
| (15, 14, 36) | 3.96 | ||
| R corpus callosum, tapetum | WM | (−26, −44, 16) | 4.15 |
| R corpus callosum, splenium | WM | (−10, −40, 16) | 4.10 |
| L superior longitudinal fasciculus | WM | (35, −13, 34) | 4.58 |
| R corona radiata, anterior | WM | (−26, 37, −16) | 3.95 |
| L corona radiata, superior | WM | (26, 5, 25) | 4.09 |
| R internal capsule, anterior limb | WM | (−17, 17, 9) | 4.07 |
| (−17, 14, 16) | 3.95 | ||
| L external capsule | WM | (28, 1, 2) | 4.00 |
| R posterior thalamic radiation | WM | (−26, −58, 7) | 4.35 |
mTBI, mild traumatic brain injury.
Assigned with reference to Talairach and Tournoux30 and John's Hopkins University71 brain atlases. R, right; L, left.
GM, gray matter; WM, white matter; GM/WM, gray matter/white matter border region.
Talairach atlas coordinates of significant between-group differences in macromolecular proton fraction by whole brain voxel-wise analyses. For x-axis, positive values are left of midline and negative values are right of midline. For z-axis, positive values are superior to plane of line connecting anterior and posterior commissures. For y-axis, positive and negative values are anterior versus posterior (respectively) of the anterior commissure.
Z-score resulting from probability integral transformation of t-value for between-group comparison at voxel coordinates given in column 3.