FIG. 2.

A20 administration was neuroprotective in vulnerable ipsilateral cortical regions 1 wk post TBI. (A and B) Representative NeuN-stained images of vehicle- (A) and A20-treated (B) animals. Selective neuronal loss was observed in the cortical region overlying the contusion site. Treatment with A20 significantly reduced NeuN-positive cell loss. Boxes in A, B enclose the areas of neuronal loss. Arrows indicate subcortical lesion. (C) Quantification of NeuN-positive cells between treatment groups revealed a significant neuroprotective effect of A20 1 wk post injury (Student's t-test: p=0.015, t=2.695; *p<0.05; scale bar, 500 μm); n=20. TBI, traumatic brain injury; NeuN, anti-neuronal nuclei.