Table 1.
Allele and genotype frequencies in AD patients and healthy controls
| AD, n (%) (n = 137) | Control, n (%) (n = 194) | p (χ2) | ||
|---|---|---|---|---|
| COMT | Genotype | 0.071 (5.300) | ||
| GG | 58 (42.3) | 97 (50.0) | ||
| GA | 61 (44.5) | 85 (43.8) | ||
| AA | 18 (13.1) | 12 (6.2) | ||
| Allele | 0.045 (4.002) | |||
| A | 97 (35.4) | 109 (28.1) | ||
| G | 177 (64.6) | 279 (71.9) | ||
| APOE | Genotype | 0.000 (43.790) | ||
| E2/E3 | 9 (6.6) | 27 (13.9) | ||
| E3/E3 | 69 (50.4) | 144 (74.2) | ||
| E2/E4 | 1 (0.7) | 0 | ||
| E3/E4 | 48 (35.0) | 21 (10.8) | ||
| E4/E4 | 10 (7.3) | 2 (1.0) | ||
| Allele | 0.000 (47.628) | |||
| E2 | 10 (3.6) | 27 (7.0) | ||
| E3 | 195 (71.2) | 336 (86.6) | ||
| E4 | 69 (25.2) | 25 (6.4) | ||
Two-tailed χ2 test for genotype distribution or allele frequency between AD patients and controls.