Figure 5.

A, at all pHs tested, peak proton-gated current magnitude was larger in DRG neurones lacking STOML1, but this failed to reach significance. B, sustained currents are significantly greater at pH 5.0 and 4.0, but not at pH 6.0 in STOML1^−/− DRG neurones. C, transient currents are significantly greater at pH 6.0, but not at lower values in STOML1^−/− DRG neurones. D, transient currents in STOML1^−/− DRG neurones inactivated significantly more rapidly at pH 4.0, but not at pH 5.0. No significant differences were observed in the magnitude of either ATP-activated (E) or voltage-gated (F) inward currents. *P < 0.05, **P < 0.01. Numbers in parentheses denote the number of recorded cells.