Table 1.
Model parameters that are held constant in the model simulations of data from wt and axJ mice
| Symbol | Definition | Value | Unit |
|---|---|---|---|
| τin | Time constant for entry into refractory state | 3 | ms |
| k0 | Baseline recovery rate from the refractory state | 2 | s−1 |
| kmax | Maximum recovery rate from the refractory state | 30 | s−1 |
| ΔD | Incremental increase in CaXD after a stimulus | 4.7 | (normalized) |
| KD | Dissociation constant of CaXD | 1 | N/A |
| τD | Decay time constant of CaXD after a stimulus | 48.8 | ms |
| KF | Dissociation constant of CaXF | 1 | N/A |
| τF | Decay constant of CaXF | 181.8 | ms |
| R | Refilling rate of readily releasable vesicle pool | 0.1 | s−1 |
CaXD, calcium-bound molecule governing the recovery from inactivation; CaXF, calcium-bound molecule governing facilitation.