Table 1.
Pharmacology of fast γ in CA1
| Drug | Concentration (μm) | n | Power change from baseline (%) | P (t test with control) | Frequency change from baseline (Hz) | P (t test with control) |
|---|---|---|---|---|---|---|
| Control | — | 9 | 123 ± 5 | — | 0.8 ± 0.3 | — |
| Pirenzepine | 10 | 4 | 3 ± 1 | 0.004 | n.a. | — |
| APV | 25 | 6 | 124 ± 14 | n.s. | 0.4 ± 0.9 | n.s. |
| MCPG | 500 | 4 | 137 ± 13 | n.s. | 0.7 ± 1.4 | n.s. |
| SYM 2206 | 10 | 6 | 8 ± 2 | 0.018 | n.a. | — |
| Bicuculline | 2 | 5 | 26 ± 5 | <0.001 | 2.3 ± 1.2 | n.s. |
| Thiopental | 20 | 14 | 152 ± 15 | 0.019 | –8.4 ± 1.0 | <0.001 |
| THIP | 1 | 6 | 41 ± 5 | <0.001 | –8.1 ± 1.0 | <0.001 |
The effect of drugs on fast γ in CA1 was assessed in CA1 minislices after 60 min in 10 μm carbachol. The changes in gamma power and dominant frequency 20 min after bath application of drugs are compared with the time-matched changes in controls, using unpaired Student's t tests. Data are given as means ± SEM, with n indicating the number of slices tested.