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. 2014 Feb 14;592(Pt 4):669–693. doi: 10.1113/jphysiol.2013.267872

Figure 3.

Figure 3

A, representative examples showing the effect of Kv7/M channel blockade (top traces) by XE991 (10 μm). Bottom traces show the effect of the Kv7/M channel opener retigabine (10 μm) on both the mAHP and sAHP. Note the reduction in holding current and depolarizing step after application of XE991 and the increase in the depolarizing step after application of retigabine. B, time plots for both the mAHP and sAHP amplitudes in a subset of cells (n = 5) recorded under control conditions, to test the stability of AHPs in our experimental conditions. Dashed lines represent the mean values during the ‘control’ period (first 5 min), in the case of drug application. C, averaged time plots of the experiments shown in A for both the mAHP and sAHP. D, summary graphs showing the effect of both XE991 (n = 7, P < 0.05 (*), P < 0.01 (**), top panels) and retigabine (n = 6, P < 0.001 (***), P < 0.01 (**), bottom panels) on the mAHP (left) and the sAHP (right).