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. 2014 Feb 14;592(Pt 4):669–693. doi: 10.1113/jphysiol.2013.267872

Figure 5.

Figure 5

A, typical examples of single AP elicited by steady depolarization near the spike threshold. In control conditions (black trace), the spontaneous AP was followed by a fAHP and mAHP. Bath application of 100 nm apamin (red) effectively blocked the mAHP, while 10 μm XE991 (green) had little or no effect on the mAHP amplitude. Right panel shows individual and averaged values for the mAHP under control and apamin (n = 6, P < 0.01 (**)) or XE991 (n = 6, P > 0.05 (NS)) conditions. B, left, overlay of averaged single APs under control (black) and apamin (red) or XE991 (green) conditions. Right, phase plots showing the dV/dt of the AP waveform plotted against the voltage. Upper panel shows that application of apamin (red) did not affect the AP threshold while XE991 (bottom panel, green) had a hyperpolarizing effect.