Figure 10.

A, typical examples of αEPSP trains at 10 (upper traces) and 40 Hz (bottom traces) before (black) and after application of 10 μm XE991 (green). B, summary plots of the number of spikes elicited by the αEPSP trains. XE991 significantly increased the number of action potentials both at 10 (n = 7, P < 0.001 (***)) and 40 Hz (n = 7, P < 0.01 (**)). C, examples shown in A at higher magnification show the reduced αEPSP absolute peak level during the mAHP (control, arrows, black traces) and the increased number of APs after XE991 (green). D, typical examples of subthreshold αEPSP trains evoked at 10 and 40 Hz during the control period (black) and after XE991 application (green). E, XE991 significantly increased the subthreshold αEPSP amplitude (n = 6, P < 0.05 (*); left panel) while having no clear effect on the αEPSP decay time constant (τ) (n = 6, P > 0.05; right panel).