Table 1.
Untransfected | Wild-type | C456S | |
---|---|---|---|
Current clamp | |||
Resting membrane potential (mV) | −61 ± 3 | −62 ± 2 | −64 ± 2 |
Input resistance (GΩ) | 0.33 ± 0.04 | 0.49 ± 0.05* | 0.47 ± 0.03 |
Number of cells | 12 | 19 | 15 |
Voltage clamp | |||
Capacitance (MΩ) | 151 ± 23 | 143 ± 11 | 125 ± 12 |
Peak current −50 mV (pA) | −98 ± 25 | −495 ± 83† | −811 ± 99* |
Number of cells | 6 | 13 | 11 |
Statistical significance was calculated for comparisons between either untransfected and wild-type or wild-type and C456S (Mann–Whitney test:
P < 0.05;
P < 0.01). Differences in Vm and capacitance were not statistically significant.