Table 1.

Electrophysiological properties of cultured hippocampal neurons in whole-cell recordings

	Untransfected	Wild-type	C456S
Current clamp
Resting membrane potential (mV)	−61 ± 3	−62 ± 2	−64 ± 2
Input resistance (GΩ)	0.33 ± 0.04	0.49 ± 0.05*	0.47 ± 0.03
Number of cells	12	19	15
Voltage clamp
Capacitance (MΩ)	151 ± 23	143 ± 11	125 ± 12
Peak current −50 mV (pA)	−98 ± 25	−495 ± 83†	−811 ± 99*
Number of cells	6	13	11

Statistical significance was calculated for comparisons between either untransfected and wild-type or wild-type and C456S (Mann–Whitney test:

^*P < 0.05;

^†P < 0.01). Differences in V_m and capacitance were not statistically significant.