Table 1.
Comparison of MIC between lauryl-PLL and conventional antibiotics.
| Bacterial strains | Lauryl-PLL (μM of linked lauric acid) |
Sensitivity and name of conventional antibiotics (μM) |
|---|---|---|
| Staphylococcus aureus | 250 | Oxacillin: 1.25 (R) |
| Benzylpenicillin: 0.75 (R) | ||
| Vancomycin: ≤0.699 (S) | ||
| Teicoplanin: ≤0.32 (S) | ||
|
| ||
| Escherichia coli | 1000 | Ampicillin: ≥91.6 (R) |
| Amikacin: 13.66 (S) | ||
| Amoxicillin: 10.95 (S) | ||
| Clavulanic acid: 20.08 (S) | ||
|
| ||
| Pseudomonas aeruginosa | 125 | Ticarcillin: ≥333 (R) |
| Ceftazidime: ≥117 (R) | ||
| Amikacin: 27 (I) | ||
| Colistin: 1.7 (S) | ||
A letter following the name of the antibiotics refers to the sensitivity to antibiotics: R: resistant; I: intermediate; S: sensitive. Based on the antibiograms of the bacterial strains tested, we selected some known and widely used conventional antibiotics, as well as polypeptide and glycopeptide antibiotics with activity similar to that with lauryl-PLL. Their sensitivity and their MICs were tested in nonresistant strains: S. aureus (Gram-positive) and P. aeruginosa, and E. coli (Gram-negative).