Fig. 1.

Body weights of C57BL/6 mice and hepatic mRNA levels of genes involved in fat synthesis. A: Beginning at 6 weeks of age, C57BL/6 mice were fed a StD or a HFD for 16 weeks. The HFD group was subdivided: HFD, was administered endotoxin-free PBS for the last 4 weeks of the diet; HFD + 2 weeks (wk) apoAI, was administered apoAI for the last 2 weeks of the diet; and HFD + 4 weeks (wk) apoAI, was administered apoAI for the last 4 weeks of the diet. Body weight was monitored once weekly (n = 10 for each treatment group). *P < 0.001 versus StD. SREBP-1 (B) and ChREBP (C) mRNA levels were measured by qPCR. mRNA levels were normalized to transcription factor IID (Tbp). Results are mean ± SEM (n = 8–10). §P < 0.05 versus StD; *P < 0.05 versus HFD.