Expression of mRNAs encoding enzymes responsible for LCA metabolism. CYP3A4, Pxr, Fxr, and Vdr mRNAs were measured by qPCR in WT, Tg-3A4, VdrΔIEpC, and VdrΔIEpC/3A4 mice. *P < 0.05 compared with control mice in the same group; +P < 0.05 compared with control in Tg-3A4 group.