TABLE 5.
Cholesterol | Phospholipids | Bile Acids | Bile Flow | |
Mttpf/f (n = 7) | 0.7 ± 0.2a | 7.0 ± 0.8a | 33.2 ± 6.3a | 1.4 ± 0.2a |
Mttp-LKO (n = 5) | 0.5 ± 0.1a | 6.2 ± 1.1a | 27.2 ± 6.7a | 1.0 ± 0.2a |
L-Fabp−/− (n = 6) | 0.7 ± 0.1a | 6.8 ± 0.4a | 21.3 ± 2.8a | 1.4 ± 0.1a |
DKO (n = 14) | 0.5 ± 0.1a | 5.6 ± 0.4a | 24.0 ± 2.6a | 1.3 ± 0.1a |
Mice from four experimental groups were fed a chow diet. Bile samples were collected for 1 h. Biliary cholesterol, phospholipids, and bile acids were analyzed (see Materials and Methods). Flow rate is expressed as μl/min/g liver weight. Biliary lipid secretion is expressed as nmol/min/g liver weight. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (P < 0.05).