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. 2014 Mar;55(3):540–548. doi: 10.1194/jlr.M046342

TABLE 6.

Biliary lipid secretion in mice of the indicated genotype on a LD

Cholesterol Phospholipid Bile Acid Bile Flow
Mttpf/f (n = 11) 4.3 ± 0.9a 21.7 ± 3.3a 81.0 ± 8.7a 1.5 ± 0.3a
Mttp-LKO (n = 8) 3.8 ± 0.4a 17.4 ± 1.6a 74.7 ± 11.7a 1.8 ± 0.4a
L-Fabp−/− (n = 7) 9.9 ± 2.5c 28.2 ± 6.1a 92.1 ± 12.9a 1.4 ± 0.1a
DKO (n = 17) 2.7 ± 0.4b 19.4 ± 2.0a 64.7 ± 5.4a 1.8 ± 0.4a

Mice from four experimental groups were fed a LD for 2 weeks. Bile samples were collected for 1 h. Biliary cholesterol, phospholipids, and bile acids were analyzed (see Materials and Methods). Flow rate is expressed as μl/min/g liver weight. Biliary lipid secretion is expressed as nmol/min/g liver weight. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (P < 0.05).