TABLE 6.
Cholesterol | Phospholipid | Bile Acid | Bile Flow | |
Mttpf/f (n = 11) | 4.3 ± 0.9a | 21.7 ± 3.3a | 81.0 ± 8.7a | 1.5 ± 0.3a |
Mttp-LKO (n = 8) | 3.8 ± 0.4a | 17.4 ± 1.6a | 74.7 ± 11.7a | 1.8 ± 0.4a |
L-Fabp−/− (n = 7) | 9.9 ± 2.5c | 28.2 ± 6.1a | 92.1 ± 12.9a | 1.4 ± 0.1a |
DKO (n = 17) | 2.7 ± 0.4b | 19.4 ± 2.0a | 64.7 ± 5.4a | 1.8 ± 0.4a |
Mice from four experimental groups were fed a LD for 2 weeks. Bile samples were collected for 1 h. Biliary cholesterol, phospholipids, and bile acids were analyzed (see Materials and Methods). Flow rate is expressed as μl/min/g liver weight. Biliary lipid secretion is expressed as nmol/min/g liver weight. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (P < 0.05).