Figure 6.
PDK1 regulates carbon entry into the TCA cycle in hypoxia. (a) Reductive glutamine contribution to citrate for different stress conditions with and without the pyruvate dehydrogenase kinase (PDK) inhibitor DCA. (b) NAD+/NADH ratio for different stress conditions. Ctrl denotes standard culture condition. All error bars indicate the standard deviation. All p-values (students T-test, two tailed, unequal variance) and error bars are calculated from three independent replicates.