Fig. 6.
Survival time distributions for binding sites randomly localized in euchromatin. For each simulation, one voxel in euchromatin (the 20th to 30th percentile of the LAC distribution) is randomly chosen to represent the binding site. Each curve is then estimated from 128,000 such simulations. Insets give the volume exclusivity, φmax, for every curve. (a) For large values of the volume exclusivity, the survival probability is no longer well-approximated by an exponential distribution for all times. (b) Reducing the scale of the t-axis we can see that as φmax is increased the survival distribution initially shifts to the left, leading to faster binding times. As φmax → ∞, the distribution shifts back to the right (Color figure online)