Table 2.

List of 27 potentially purpura fulminans-associated proteins (SpC_PF/N ≥ 2 or ≤0.5) identified by HPLC-Chip/MS across the two biological groups.

Gene symbol	Protein name	Protein function	% AA coverage	Distinct peptides	SpCPF/N	Up-/downregulation
AGT	Angiotensinogen	Maintain blood pressure	18	7	10.32	Up
ALDOB	Fructose-bisphosphate aldolase B	Glycolysis	13	4	38.69	Up
APCS	Serum amyloid P-component	Amyloidosis	16	3	2.06	Up
APOC3	Apolipoprotein C-III	Lipoprotein metabolism	27	2	2.06	Up
APOD	Apolipoprotein D	Lipoprotein metabolism	25	4	2.32	Up
C1QC	Complement C1q subcomponent subunit C	Complement system	17	3	3.1	Up
C7	Complement component 7	Complement system	6	3	0.04	Down
C8G	Complement component 8 gamma	Complement system	23	3	0.04	Down
CFI	Complement factor I	Complement system	6	3	4.64	Up
CPN2	Carboxypeptidase N subunit 2		5	2	6.19	Up
F5	Coagulation factor V	Coagulation cascade	2	4	0.05	Down
FGA	Fibrinogen alpha chain	Coagulation cascade	4	3	67.7	Up
GC	Vitamin D binding protein	Bind vitamin D	25	11	2.58	Up
GSN	Gelsolin	Assembly and disassembly of actin filaments	16	8	0.23	Down
IGFALS	Insulin-like growth factor binding protein complex acid labile chain	Bind insulin-like growth factors	7	3	3.35	Up
LBP	Lipopolysaccharide-binding protein	Immune response	8	3	17.03	Up
LRG1	Leucine-rich alpha-2-glycoprotein 1	Signal transduction	20	6	2.63	Up
LUM	Lumican	Collagen fibril organization	5	2	3.16	Up
ORM2	Alpha-1-acid glycoprotein 2	Acute phase response	21	4	3.41	Up
PGLYRP2	N-acetylmuramoyl-L-alanine amidase	Digest peptidoglycan	4	2	0.02	Down
PKM2	Pyruvate kinase isozymes	Glycolysis	4	2	38.69	Up
SAA	Serum amyloid A protein	Acute phase protein	39	3	58.03	Up
SERPINA1	Alpha-1-antitrypsin	Serine protease inhibitors	20	8	145.08	Up
SERPINA6	Corticosteroid-binding globulin	Transport glucocorticoids	6	2	3.16	Up
SERPINA7	Thyroxine-binding globulin	Transport thyroid hormone	4	2	0.02	Down
SERPINF1	Pigment epithelium derived factor	Inhibit angiogenesis	5	2	29.02	Up
SERPINF2	Alpha-2 antiplasmin	Coagulation cascade	8	3	0.39	Down