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Summary of agonist EC50 values for multiple substitutions at GluN2A Leu812
| Glutamate EC50, μM | Glycine EC50, μM | |
|---|---|---|
| WT 2A | 3.6 ± 0.4 (8) | 1.1 ± 0.2 (6) |
| 2A-L812G | 1.4 ± 0.03 (10) | 0.24 ± 0.03 (9) |
| 2A-L812S | 0.31 ± 0.04 (12) | 0.10 ± 0.01 (10) |
| 2A-L812C | 1.1 ± 0.25 (10) | 0.33 ± 0.04 (12) |
| 2A-L812A | 0.68 ± 0.10 (10) | 0.20 ± 0.02 (12) |
| 2A-L812Q | 0.67 ± 0.09 (8) | 0.14 ± 0.01 (13) |
| 2A-L812E | 0.90 ± 0.07 (10) | 0.16 ± 0.01 (12) |
The data were expressed as Mean ± SEM (n).
