Table 1.
Electrical heterogeneity and remodelling in the PV-LA regiona
| ICa,L (pA/pF) | IK1 (pA/pF) | Ito (pA/pF) | IKs (pA/pF) | IKur (pA/pF) | APD (ms) | |
|---|---|---|---|---|---|---|
| LA control | 8.0 (8.5) | 5.0 (5.8) | 9.0 (8.4) | 5.0 (5.3) | 10.0 | 185 (195) |
| PV control | 6.0 (5.9) | 3.5 (3.6) | 4.5 (5.6) | 9.0 (9.8) | 10.0 | 173 (175) |
| LA remodelled | 4.0 (3.4) | 10.0 (9.3) | 4.0 (3.6) | 5.0 (5.0) | 5.0 | 112 (125) |
| PV remodelled | 3.0 (2.6) | 7.0 (6.1) | 2.0 (2.8) | 9.0 (9.8) | 5.0 | 107 (130) |
aIon channel current densities and APDs for the PV and LA cell models under control and full remodelling conditions. Simulated values are in good agreement with the respective experimental values12 shown in brackets. Note that the current density of IKur (step current) in control is the same as in the original paper by Ramirez et al.26 The current density of IKur in remodelling conditions is halved as seen in human atrial cells.10