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No changes were observed in mean blood flow response to increasing dosage of vasoactive substances between any of the four groups during the year intervention: exercise training & Alagebrium (solid line + ●), exercise training & placebo (solid line + ○), control & Alagebrium (dashed line + ■), and control & placebo (dashed line + □). Pre = baseline measurements, post = after 1-year interventions.
