Figure 3. Accumulation of phosphorylated tau was detected in neurites surrounding amyloid plaques in the brain of S100A9 crossbred mice at 14 months old.

Phosphorylated tau (P-tau) was detected in the hippocampus and cortex of WT/Tg and KO/Tg mice brains by immunohistochemistry. The amount of P-tau was significantly reduced in KO/Tg mice brains compared with WT/Tg mice brains. (h) – (j) are P-tau stained region of (c) and (g). Sections are 4 µm thick. ((a) – (h) Scale bar; 200 µm, (h) – (k) scale bar; 50 µm).