Table 3. The 20 genes most strongly upregulated by S1P in 3D cultured keratinocytes.
| Name | ratio | RefSeq_ID | description |
| TNF | 15.5 | NM_000594 | Tumor necrosis factor precursor (TNF-alpha) |
| CXCL1 | 13.9 | - | Growth regulated protein alpha precursor (CXCL1) |
| EDN1 | 12.0 | - | Endothelin-1 precursor (Preproendothelin-1) |
| KRTAP3-2 | 11.3 | NM_031959 | Keratin-associated protein 3-2 |
| Q9NPD2_HUMAN | 10.9 | - | Keratin 19 |
| KRT19 | 10.6 | NM_002276 | Keratin, type I cytoskeletal 19 (Cytokeratin 19) |
| DMBX1 | 10.6 | NM_172225 | diencephalon/meSensephalon homeobox 1 isoform a |
| DB105_HUMAN | 10.3 | NM_152250 | Beta-defensin 105 precursor (Beta-defensin 5) |
| FOS | 10.2 | NM_005252 | Proto-oncogene protein c-fos(Cellular oncogene fos) |
| HIST1H1BB | 9.2 | NM_021052 | Histone H1B.m (H1B/m) |
| NP_853640.1 | 9.2 | NM_181609 | Keratin-associated protein 19-3 |
| KRTAP19-1 | 8.6 | NM_181607 | Keratin-associated protein 19-1 |
| CXCL2 | 8.4 | NM_002089 | Macrophage inflammatory protein-1Blpha precursor (CXCL2) |
| NP_004684.1 | 8.4 | NM_004693 | cytokeratin type II |
| GADD45G | 7.9 | NM_006705 | Growth arrest and DNA-damage-inducible protein GADD45 gamma |
| IL8 | 7.7 | NM_000584 | Interleukin-8 precursor (IL-8) |
| TFPI2 | 7.7 | NM_006528 | Tissue factor pathway inhibitor 2 precursor (TFPI-2) |
| IRF1 | 7.7 | - | Interferon regulatory factor 1 (IRF-1). |
| IL23A | 7.5 | NM_016584 | interleukin 23, alpha subunit p19 precursor |
| NP_853642.1 | 7.1 | NP_853642.1 | Keratin-associated protein 19-5 |
The results shown are representative data of 3 experiments.